Abstract
Abstract Based on a semirigid tricarboxylate ligand 5-((4-carboxyphenoxy)methyl)benzene-1,3-dioic acid (H3L), a new Pb(II)-based coordination polymer formulated as [Pb(HL)(H2O)](H2O) (1) was synthesized under solvothermal conditions and characterized by single-crystal X-ray structural analysis, power X-ray diffraction, and elemental analysis. Compound 1 is a two-dimensional layered structure formed by the connection of the one-dimensional Pb(II)-based secondary building unit chains with the partly deprotonated HL ligands, which are further extended into three-dimensional supermolecular structures through the H-bonds. Furthermore, the size of the as-prepared 1 could be downsized into the nano region through a simple ultrasonic method. Finally, the antilung cancer activities of 1 and the nanosized 1 have been probed via the MTT assay against three human lung cancer cell lines (A549, H1299, and PC9).
Highlights
The anti-lung cancer activities of 1 and the nanosized 1 have been probed through the MTT assay against three human lung cancer cell lines (A549, H1299, and PC9)
The adjacent 2D layers are further extended into 3D supermolecular structure through the H-bonds between the coordinated water molecule and the undeprotonated carboxylic groups on the HL ligand with a short O · · · H-O distance of 1.842(3) Å (Figure 2D)
To preliminary access the anticancer efficacies of the two complexes (1 and nano-1), their tumor cell growth inhibition activity against human lung cancer cell lines (A549, H1299, and PC9) was evaluated by MTT cell viability assay with doxorubicin as the reference drug
Summary
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