Abstract
A new pathway regulating autophagy
Highlights
Autophagy is required to remove damaged organelles and proteins in all healthy tissues
Autophagy is negatively regulated by mTOR signaling complex 1 activation
When mTOR signaling complex 1 (mTORC1) is inactivated in response to nutrient or growth factor deprivation, autophagy is induced by the formation of a multiprotein kinase complex primarily composed of autophagy proteins (ATG) leading to the nucleation of the autophagosome
Summary
Autophagy is required to remove damaged organelles and proteins in all healthy tissues. In several tissues, including the liver [3] and heart [4], autophagy is an alternative pathway to acquire fatty acids. ATG regulation and autophagosome formation are not completely understood, so autophagic flux must be measured by a functional readout, i.e., examining autophagosome morphology and quantity as well as microtubule-associated protein 1A/1Blight chain 3 (LC3) lipidation [1, 5].
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