Abstract
BackgroundThyroid cancer is a common malignant disease of the endocrine system with increasing incidence rates over the last few decades. In this study, we sought to analyze the possible association of 45 single nucleotide polymorphisms (SNPs) with thyroid cancer in a population from Rio Grande do Norte, Brazil.MethodsBased on histological analysis by a pathologist, 80 normal thyroid specimens of tissue adjacent to thyroid tumors were obtained from the biobank at the Laboratory of Pathology of Liga Norte Riograndense Contra o Câncer, Natal, RN. Patient samples were then genotyped using the MassARRAY platform (Sequenon, Inc) followed by statistical analysis employing the SNPassoc package in R program. The genotypic frequencies of all 45 SNPs obtained from the International HapMap Project database and based on data from the ancestral populations of European and African origin were used to compose the control study group.ResultsIn our study, the following 9 SNPs showed significant differences in their frequency when comparing the study and control groups: rs3744962, rs258107, rs1461855, rs4075022, rs9943744, rs4075570, rs2356508, rs17485896, and rs2651339. Furthermore, the SNPs rs374492 C/T and rs258107 C/T were associated with a relative risk for thyroid carcinoma of 3.78 (p = 6.27 × 10e−5) and 2.91 (p = 8.27 × 10e−5), respectively, after Bonferroni’s correction for multiple comparisons.ConclusionsThese nine polymorphisms could be potential biomarkers of predisposition to thyroid carcinoma in the population from Rio Grande do Norte. However, complementary studies including a control group with samples obtained from healthy subjects in Rio Grande do Norte state, should be conducted to confirm these results.
Highlights
Thyroid cancer is a common malignant disease of the endocrine system with increasing incidence rates over the last few decades
Well differentiated thyroid carcinomas (WDTC) are further subdivided histologically dos Santos et al BMC Medical Genetics (2017) 18:140 as papillary thyroid carcinoma and follicular thyroid carcinoma, which correspond to 80% and 10% of thyroid carcinomas, respectively [5]
Eighty Thyroid cancer (TC) patients from Brazil were genotyped for 45 single nucleotide polymorphisms (SNPs), to identify potential molecular markers of predisposition to this neoplasia
Summary
Thyroid cancer is a common malignant disease of the endocrine system with increasing incidence rates over the last few decades. If the observed trends are maintained, TC will replace colorectal cancer as the fourth leading cancer diagnosis in the United States by 2030 [2] Such an increase is likely due to improved diagnosis, and largely or completely reflects the over diagnosis of indolent disease [3]. Well differentiated thyroid carcinomas (WDTC) are further subdivided histologically dos Santos et al BMC Medical Genetics (2017) 18:140 as papillary thyroid carcinoma and follicular thyroid carcinoma, which correspond to 80% and 10% of thyroid carcinomas, respectively [5]. Both these carcinomas can progress to poorly differentiated carcinoma or completely lose differentiation, giving rise to anaplastic carcinoma [6]. Parafollicular cell-derived medullary carcinoma accounts for about 5% of thyroid carcinomas [5, 7]
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