A new NIR emission mitochondrial targetable fluorescent probe and its application in detecting viscosity changes in mouse liver and kidney injury

Abstract

As important organs of the human body, the liver and kidneys ensure the stability of the internal environment of the body and allow the body to carry out normal metabolism. The lack of effective methods for early diagnosis of liver and kidneys diseases is an important reason for delaying the treatment of kidney diseases. Therefore, the development of a simple, non-invasive and effective test is essential for the early diagnosis of liver and kidneys disease. Herein, a new viscosity fluorescent probe, Mito-ND, is rationally designed and synthesized in order to solve the practical problem of realizing the diagnosis of liver and kidneys diseases. The constructed fluorescent probe Mito-ND has the advantages of near-infrared emission, mitochondrial localization, high chemical and photo-stable properties, and sensitive viscosity detection performance, etc. Using this fluorescent probe, besides in vitro cell viscosity fluorescence imaging, the viscosity fluorescence imaging of mouse liver and kidney injury are also achieved for the first time. Mito-ND provides more accurate tools for the non-invasive diagnosis of viscosity-related diseases such as liver injury and kidney injury. Therefore, Mito-ND provides more accurate detection techniques for the early diagnosis of liver and kidney diseases such as liver injury and kidney injury.