A new nickel-based co-crystal complex electrocatalyst amplified by NiO dope Pt nanostructure hybrid; a highly sensitive approach for determination of cysteamine in the presence of serotonin

Hassan Karimi-Maleh,Ghobad Mansouri,Fatemeh Karimi,Amir Razmjou,Aysenur Aygun,Yasin Orooji,Fatih Sen

doi:10.1038/s41598-020-68663-2

Abstract

A highly sensitive electrocatalytic sensor was designed and fabricated by the incorporation of NiO dope Pt nanostructure hybrid (NiO–Pt–H) as conductive mediator, bis (1,10 phenanthroline) (1,10-phenanthroline-5,6-dione) nickel(II) hexafluorophosphate (B,1,10,P,1,10, PDNiPF6), and electrocatalyst into carbon paste electrode (CPE) matrix for the determination of cysteamine. The NiO–Pt–H was synthesized by one-pot synthesis strategy and characterized by XRD, elemental mapping analysis (MAP), and FESEM methods. The characterization data, which confirmed good purity and spherical shape with a diameter of ⁓ 30.64 nm for the synthesized NiO–Pt–H. NiO–Pt–H/B,1,10, P,1,10, PDNiPF6/CPE, showed an excellent catalytic activity and was used as a powerful tool for the determination of cysteamine in the presence of serotonin. The NiO–Pt–H/B,1,10, P,1,10, PDNiPF6/CPE was able to solve the overlap problem of the two drug signals and was used for the determination of cysteamine and serotonin in concentration ranges of 0.003–200 µM and 0.5–260 µM with detection limits of 0.5 nM and 0.1 µM, using square wave voltammetric method, respectively. The NiO–Pt–H/B,1,10,P,1,10,PDNiPF6/CPE showed a high-performance ability for the determination of cysteamine and serotonin in the drug and pharmaceutical serum samples with the recovery data of 98.1–103.06%.

Highlights

A highly sensitive electrocatalytic sensor was designed and fabricated by the incorporation of NiO dope Pt nanostructure hybrid (NiO–Pt–H) as conductive mediator, bis (1,10 phenanthroline) (1,10-phenanthroline-5,6-dione) nickel(II) hexafluorophosphate (B,1,10,P,1,10, PDNiPF6), and electrocatalyst into carbon paste electrode (CPE) matrix for the determination of cysteamine
The FESEM figure showed a spherical shape for synthesized NiO–Pt–H with good distribution in nanoparticle sizes (Fig. 2A)
The results showed a linear relation between oxidation current of cysteamine and its concentration in the range of 0.003–200 μM with equation Ipa = 0.0385 Ccysteamine + 0.9602 (R2 = 0.9978) and a linear range between 0.5 and 260 μM with equation Ipa = 0.0238 CSerotonin + 0.4139 (R2 = 0.9969) for the determination of serotonin on the surface of NiO–Pt–H/B,1,10,P,1,10,PDNiPF6/CPE

Summary

Introduction

A highly sensitive electrocatalytic sensor was designed and fabricated by the incorporation of NiO dope Pt nanostructure hybrid (NiO–Pt–H) as conductive mediator, bis (1,10 phenanthroline) (1,10-phenanthroline-5,6-dione) nickel(II) hexafluorophosphate (B,1,10,P,1,10, PDNiPF6), and electrocatalyst into carbon paste electrode (CPE) matrix for the determination of cysteamine. Inorganic complexes, especially complexes with nickel central atom can be used as a suitable electrocatalyst in the analysis of important pharmaceutical and biological constituents47–52 Nanomaterials such as carbon nanotubes and graphene with high-conductivity have been proposed for the preparation of electrochemical sensors, their high cost, hard synthesis methods, and high capacitive charging current are some of the most important criteria for their use in electrochemical s ensors. In this study, we fabricated NiO–Pt–H/B,1,10,P,1,10,PDNiPF6/CPE as a first and highly sensitive electroanalytical sensor for simultaneous determination of cysteamine and serotonin. The Ag/AgCl/KClsat and electrochemical cell were purchased from Azar Electrode Company

Methods

Results

Conclusion