A new monoterpenoid glycoside and a new phenolic glycoside isolated from Dracocephalum moldavica and their anti-complementary activity

Abstract

A new monoterpenoid glycoside (1 R, 2 R, 4S)-1,8-epoxy-p-menthan-2-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside (1) and a new phenolic glycoside, cis-1-(3-hydroxy-4-methoxyphenyl)-2-butene-4-O-α-L-rhamnopyranosyl-(1→3)-O-β-D-glucopyranoside (2) were isolated from the dried aerial parts of Dracocephalum moldavica, together with 12 known compounds. Compound 5 was isolated from the Lamiaceae family for the first time, compounds 3, 4, 6 and 8–12 were identified from the genus Dracocephalum for the first time and compounds 7 and 13–14 were reported from the D. moldavica for the first time. All the compounds were evaluated for anti-complementary activity against the classical and alternative pathways. Compounds 2–4, 8 and 11 showed anti-complementary activity to different extents, with CH50 and AP50 values ranging from 0.78–1.24 and 1.52–1.84 mM, respectively. The targets of compounds 2–4, 8 and 11 in complement activation cascade were identified as well.