Abstract
Background Accurate characterization of myocardial scar has important diagnostic and prognostic implications for post-infarct patients. Previous studies have used late gadolinium enhanced (LGE) MR to characterize myocardial scar, by dividing the scar region into core and gray zones based on signal intensity in LGE. The characterization is however subjective to manual annotations, dependent on image acquisition parameters, contrast dose and timing, and has limited reproducibility. The purpose of this study is to objectively and reproducibly characterize infarcted myocardial tissue combining information from the LGE and post-contrast Look-Locker (LL) sequences.
Highlights
Accurate characterization of myocardial scar has important diagnostic and prognostic implications for post-infarct patients
Previous studies have used late gadolinium enhanced (LGE) MR to characterize myocardial scar, by dividing the scar region into core and gray zones based on signal intensity in LGE
Prior to the LGE acquisition, a LL sequence was acquired at one short-axis level to determine the optimal inversion time for LGE, and to estimate the T1 values of blood and myocardium
Summary
Accurate characterization of myocardial scar has important diagnostic and prognostic implications for post-infarct patients. Previous studies have used late gadolinium enhanced (LGE) MR to characterize myocardial scar, by dividing the scar region into core and gray zones based on signal intensity in LGE. The characterization is subjective to manual annotations, dependent on image acquisition parameters, contrast dose and timing, and has limited reproducibility. The purpose of this study is to objectively and reproducibly characterize infarcted myocardial tissue combining information from the LGE and post-contrast Look-Locker (LL) sequences
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