Abstract
AbstractFrom the methanol extract of the marine sponge Hippospongia fistulosa Lendenfeld, 1889, a new meroterpene lactone named as hippolactone A (1), a new alkyl amino alcohol named as 2‐aminotetradec‐13‐ene‐3,4,5,6,7‐pentaol (2), and three known meroterpenes, polyfibrospongol A (3), polyfibrospongol B (4), and 19‐hydroxy‐polyfibrospongol B (5), were isolated. Their structures were elucidated by extensive spectroscopic analyses including IR, HR‐ESI‐MS, 1D and 2D NMR, and by comparison of the spectral data with those of previously reported data. Compounds 1 and 2 exhibited cytotoxic effects on Hep‐G2, MCF‐7, SK‐LU‐1, and SK‐Mel‐2 human cancer cells with percentages of dead cells in the range from 18.2±1.1 % to 43.4±1.6 %.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have