Abstract
Previously unreported meroterpene, acremine S (1), and benzopyran derivative, acremine T (2), were isolated, together with lumichrome (3), ergosterol (4) and ergosterol 5,8-endoperoxide, from cultures of the marine sponge-associated fungus Acremonium persicinum KUF1007. The structure of the previously unreported compounds was established based on an extensive analysis of 1D and 2D NMR spectra as well as HRMS data. The absolute configurations of the stereogenic centers of 1 were established, unambiguously, based on NOESY correlations and comparison of calculated and experimental electronic circular dichroism (ECD) spectra. Compounds 1–3 were tested for their in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activities.
Highlights
The genus Acremonium (Hypocreaceae) includes approximately 100 species and are known as saprobic on dead plants or soil dwellers [1]
Inspired by these few and recent findings, in our ongoing search for new bioactive compounds from marine-derived fungi, from the Gulf of Thailand, we investigated secondary metabolites from the cultures of A. persicinum KUFA1007, which was isolated from the marine sponge Mycale sp., collected from the coral reef at Samaesarn Island, Chonburi Province, in the Gulf of Thailand
Since only a few compounds from marine-derived fungi have been tested for neuroprotective activities, we have isolated secondary metabolites produced by marine-derived fungi to investigate their capacity as cholinesterase inhibitors
Summary
The genus Acremonium (Hypocreaceae) includes approximately 100 species and are known as saprobic on dead plants or soil dwellers [1]. Liu et al [16] have found that the ethyl acetate extract of the cultures of Aspergillus ochraceus SH0701, isolated from the sea sediment in China, potently inhibited acetylcholinesterase; they did not isolate the compounds from this active extract. Inspired by these few and recent findings, in our ongoing search for new bioactive compounds from marine-derived fungi, from the Gulf of Thailand, we investigated secondary metabolites from the cultures of A. persicinum KUFA1007, which was isolated from the marine sponge Mycale sp., collected from the coral reef at Samaesarn Island, Chonburi Province, in the Gulf of Thailand.
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