Abstract
A new megastigmane glycoside, gangeticoside (1), and three known compounds leonuriside A (2), methyl benzoate 2-O-β-D-glucopyranoside (3), and tortoside A (4) were isolated from the aerial part of Desmodium gangeticum. Their structures were determined by 1D and 2D NMR spectra. The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. Among them, compounds 1, 2, and 3 exhibited strong effect with the IC50 values of 22.3, 15.6, 7.3 μM, respectively.
Highlights
Desmodium gangeticum (L.) DC. is a woody perennial herb plant, which distributed wildly in the mountainous area in Vietnam, or several regions in Asia and Africa [1, 2]
We reported the isolation of a new megastigmane glycoside 1 and three known compounds from D. gangeticum (Figure 1). e isolated compounds were evaluated for their inhibition of nitric oxide (NO) production in LPS-stimulated RAW264.7 cells
Based on the above analysis, the structure of compound 1 was elucidated as a new megastigmane glycoside, which was named gangeticoside
Summary
Desmodium gangeticum (L.) DC. is a woody perennial herb plant, which distributed wildly in the mountainous area in Vietnam, or several regions in Asia and Africa [1, 2]. Previous studies proved the contents of flavonoids, alkaloids, and sterols in D. gangeticum with hepatoprotective, antiinflammatory, antileishmanial, immunomodulatory, cardioprotective, antinociceptive wound healing, antidiabetic, and antiulcer activities [3,4,5,6]. Nitric oxide (NO) has been known to involve in the regulation of various physiological processes in mammals and the overproduction of NO is responsible for the pathological development of inflammation, cancer, and diabetes [7, 8]. Erefore, inhibitors of NO production have potential therapeutic value as anti-inflammatory agents [9]. We reported the isolation of a new megastigmane glycoside 1 and three known compounds from D. gangeticum (Figure 1). E isolated compounds were evaluated for their inhibition of nitric oxide (NO) production in LPS-stimulated RAW264.7 cells We reported the isolation of a new megastigmane glycoside 1 and three known compounds from D. gangeticum (Figure 1). e isolated compounds were evaluated for their inhibition of nitric oxide (NO) production in LPS-stimulated RAW264.7 cells
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