A new megastigmane diglycoside from Litsea glutinosa (Lour.) C. B. Rob.

Yun-Song Wang,Hong-Bing Zhang,Rong Huang,Zhen Liao,Jing-Hua Yang,Yan Li

doi:10.1590/s0103-50532011001100030

Yun-Song Wang, Hong-Bing Zhang + Show 4 more

Open Access

https://doi.org/10.1590/s0103-50532011001100030

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Abstract

Phytochemical study on the leaves and twigs of afforded the new megastigmane diglycoside (6S, 7E, 9R)-6, 9-dihydroxy-4, 7-megastigmadien-3-one-9-O-[α-L-arabinofuranosyl-(l→6)]-β-D-glucopyranoside (1), along with glycosides (6S, 7E, 9R)-roseoside (2), (7'R, 8'R)- 3, 5'-dimethoxy-9, 9'-dihydroxy-4, 7'-epoxylignan 4'-β-D-glucopyranoside (3), (7'R, 8'S)-dihydrodehydrodiconifenyl alcohol 9'-O-β-D-xylopyranoside (4) and pinoresinol 3-O-β-D-glucopyranoside (5). Their structures were established on the basis of extensive spectroscopic and chemical methods. Compounds 2-5 were reported for the first time in this species. Compound 1 was evaluated for cytotoxic activities against human tumor cell lines (myeloid leukemia HL-60, hepatocellular carcinoma SMMC-7721, lung cancer A-549, breast cancer MCF-7 and colon cancer SW480 cells), for which it was proved to be inactive (IC50 > 40 µM).

Highlights

Litsea (Lauraceae) is a genus of about 200 species mainly growing in tropical and subtropical Asia, some distributed in Australia and from North America to subtropical South America
Rob. is an evergreen tree known in China as “Chan Gao Shu”
The leaves and twigs of L. glutinosa (Lour.) have been used as a demulcent and mild astringent for diarrhea and dysentery, whereas the roots are used in local folk medicine to poultice sprains and bruises.[1]

Summary

Introduction

Litsea (Lauraceae) is a genus of about 200 species mainly growing in tropical and subtropical Asia, some distributed in Australia and from North America to subtropical South America. The present study resulted in the characterization of a new megastigmane diglycoside (1), along with known compounds (6S, 7E, 9R)-roseoside (2), (7'R, 8'R)3, 5'-dimethoxy-9, 9'-dihydroxy-4, 7'-epoxylignan 4'-b-D-glucopyranoside (3), (7'R, 8'S)-dihydrodehydrodiconifenyl alcohol 9'-O-b-D-xylopyranoside (4), and pinoresinol 3-O-b-D-glucopyranoside (5), from the EtOH extract of L. glutinosa leaves and twigs.

Results

Conclusion