Abstract
Pharmacologic treatments for alcohol dependence have modest efficacy and tolerability. These researchers conducted a double-blind, controlled trial of the alpha-1 adrenergic antagonist prazosin for alcohol dependence. The research was based on animal studies implicating noradrenergic circuits in alcohol consumption and reinforcement, prazosin-induced reductions in alcohol intake in alcohol-preferring rats ( Alcohol Clin Exp Res …
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