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Abstract
Biological changes underlying T lymphocyte activation, are known to be complex and are still poorly understood (1). Prominent in the early activation-related phenomena (minutes to a few hours after the activation signal) are the elevation of cytoplasmic calcium and changes in transmembrane electrical potential (TMP) (2–4). Resting T lymphocytes possess a relatively constant TMP. However, following mitogen or antigen challenge, T cell TMP changes over several minutes to hours with consecutive periods of depolarization, repolarization and hyperpolarization (2). Selective membrane NA, K-ATP-ase, and the K and Na permeable channels, abrogate both the TMP changes and T cell activation indicating a relationship between them and suggesting that cell membrance depolarization is an integral part of cell activation (2).
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