Abstract
A new lignan, named (8S, 8′S)-2,2',3,3'-tetramethoxy-4'-hydroxy-epoxylignan-4-O-β-D-glucoside (1), together with eight known compounds (2–9), was isolated from the leaves of P. tectorius. Their structures were elucidated on the basis of spectral characteristics and comparison with the data of literatures. Besides, the absolute configuration of 1 was established by using ECD calculations. The cytotoxicity of 1 in vitro against three selected tumor cell lines (A549, HeLa and MCF-7) was evaluated by MTT assay. The results showed that compound 1 exhibited moderate cytotoxicity against HeLa cell with IC50 value of 19.30 ± 4.46 μM.
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