Abstract
A new simple and sensitive kinetic spectrophotometric method has been proposed for the determination of cefadroxil in pure form and pharmaceutical formulations. The proposed method is based on the formation of yellow coloured product (λmax = 410 nm) that resulted after addition of the reagent, which is composed of a mixture of Henna extract, sodium hydroxide and potassium permanganate, to cefadroxil aqueous solution. The experimental conditions have been optimized. Beer’s law is obeyed over the concentrations of 100 - 35 μg/ml, with a linear regression correlation coefficient of 0.996. The proposed method has been successfully applied for the determination of cefadroxil in pharmaceutical dosage forms.
Highlights
Cefadroxil an orally active cephalosporin (Figure 1) [1], it is antibacterial used in treatment of mild to moderate infections caused due to susceptible microorganism [2], and to treat bacterial infections of the skin, ear, soft tissues, strep throat and the urinary tract [3]
In this work we aim to use a mixture of potassium permanganate and Henna extract as a reagent for determination of cefadroxil spectrophotometrically
No reports in literature have been found for the use of Henna extract as natural reagents in chemical analysis and this work might be the first attempt to do so
Summary
Cefadroxil an orally active cephalosporin (Figure 1) [1], it is antibacterial used in treatment of mild to moderate infections caused due to susceptible microorganism [2], and to treat bacterial infections of the skin, ear, soft tissues, strep throat and the urinary tract [3]. How to cite this paper: Hassan, M., et al (2014) A New Kinetic Spectrophotometric Method for Determination of Cefadroxil in Pharmaceutical Formulations Using Lawsonia inermis (Henna) as Natural Reagent. In this work we aim to use a mixture of potassium permanganate and Henna extract as a reagent for determination of cefadroxil spectrophotometrically. Lawsone is responsible for the colorant property of Henna leaves [20] This molecule has an affinity for bonding with protein and has been used to dye skin, fingernails, hair, leather, silk and wool [21]. No reports in literature have been found for the use of Henna extract as natural reagents in chemical analysis and this work might be the first attempt to do so. The stoichoimetry and kinetics of the reaction have been investigated
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