A NEW KIND THERAPY OF ENDOMETRIOSIS USE A NOVEL BIOMATERIAL GLUE

Abstract

Endometriosis, a disease that affects the physical health and emotional well-being of many women of reproductive age, is defined as the presence of endometrial tissue outside its normal location in the uterus. Treatment options include expectant management, hormonal therapies to suppress ovarian steroidogenesis and induce endometrial atrophy and surgery to remove visible lesions or, as a last resort, the uterus and ovaries. Although treatment methods have improved considerably in recent years, but cure women with unexplained pelvic pain or infertility that may he refer for further evaluation. In our present study, we examined the growth-inhibitory effect of new type of biological glue of poly(glycolic acid), or PGA on endometriosis during endoscopic surgery. Using DNA fragmentation analysis by agarose gel electrophoresis, and cellular viability change was assessed by staining nuclei of cells with propidium iodide, or PI, and apoptosis assays using mitochondrial stain, nonyl acridine or, orange is reported to hind to cardiolipin in the inner mitochondrial membrane. Its fluorescence decreases as cardiolipin becomes oxidized or otherwise altered during apoptosis. Our found that the new type of biological glue of PGA induced apoptosis in cultured primary endomerial epithelial cells. This is the first study to show that new type of biological glue of PGA directly inhibits cell proliferation by inducing apoptosis, and we suggest that this new type of biological glue may be applicable for endometriosis therapy.Figure 1: Caption Not Available.