Abstract
A new isoflavonoid, 5,6-dimethoxy-2',3'-methylenedioxy-7-C-β-d-gluco-pyranosyl isoflavone was isolated from the seeds of Lepidium sativum L. along with two known isoflavonoids, 7-hydroxy-4',5,6-trimethoxyisoflavone and 7-hydroxy-5,6-dimethoxy-2',3'-methylenedioxyisoflavone. The structures of all compounds were elucidated with NMR spectrometry. Compounds 1, 2 and the new isoflavonoid 3 were evaluated for their ability to reduce the hepatotoxicity induced by paracetamol in male rats by reducing the damage and toxicity effects on liver cells with a significant improvement of total antioxidant capacity, normalizing the levels of liver enzymes GSH, SOD, GPX, CAT and GST compared to control group.
Highlights
IntroductionL. sativum (family Cruciferae) grows in Egypt by three species: L. latifolium, L. sativum and
L. sativum grows in Egypt by three species: L. latifolium, L. sativum andL. aucheri, of which the most common one is L. sativum [1]
It was found that oral administration of aqueous extract of L. sativum caused a significant drop in blood pressure [4]
Summary
L. sativum (family Cruciferae) grows in Egypt by three species: L. latifolium, L. sativum and. L. sativum is popular medical treatments used in the Kingdom of Saudi Arabia, Sudan and some other Arab countries and mediator well for healing broken bones in the human skeleton. He noted a number of recent studies of the traditional uses of L. sativum seed extract in control of many of the clinical problems. It was found that oral administration of aqueous extract of L. sativum caused a significant drop in blood pressure [4]. Some of these activities are responsible for the ability of. We report the isolation of a new one and two of the known compounds and in vivo study of the effects of the new complex liver 3 and two other compounds 1 and 2 against liver damage caused by paracetamol
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