Abstract
A new sesquiterpene polyol ester with a β-dihydroagarofuran skeleton, NW37 (1), and three known compounds NW13 (2), NW16 (3) and NW35 (4) were isolated by bioassay-guided fractionation from the highly polar MeOH extracts of the root bark of Celastrus angulatus. Their chemical structures were elucidated mainly by analyses of MS and NMR spectral data. The insecticidal activity of compound 1 against 4th instar Mythimna separata larvae with a KD50 value of 252.3 μg·g-1 was demonstrated.
Highlights
Various β-dihydroagarofuran sesquiterpene polyol esters and pyridine alkaloids, some of which exhibit insect antifeedant, insecticidal, antitumor, reversing multidrug resistance, anti-HIV, and immunosuppressive activities, have been obtained from the plants of the Celastraceae family [1,2,3,4,5,6,7,8,9,10].Celastrus angulatus, a plant of the this family, is widely distributed in China and used for the treatment of rheumatism in traditional Chinese medicine and as an insecticide [11,12]
Some antifeedant, narcotic, and insecticidal ingredients were isolated from the toluene extracts of the root bark of C. angulatus
Four sesquiterpene polyol esters 1-4 were isolated from the MeOH extracts of the root bark of C
Summary
Various β-dihydroagarofuran sesquiterpene polyol esters and pyridine alkaloids, some of which exhibit insect antifeedant, insecticidal, antitumor, reversing multidrug resistance, anti-HIV, and immunosuppressive activities, have been obtained from the plants of the Celastraceae family [1,2,3,4,5,6,7,8,9,10]. Some antifeedant, narcotic, and insecticidal ingredients were isolated from the toluene extracts of the root bark of C. angulatus. To obtain a sufficient number of compounds for QSAR research on their insecticidal activity against Mythimna separata, the chemical constituents from the root bark of Molecules 2009, 14. C. angulatus were re-investigated guided by activity-guided fractionation. These studies have led to the isolation of a novel sesquiterpene polyol ester NW37 (1). The isolation, structure elucidation and insecticidal activity of compound 1 were presented
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