Abstract
Summary 1. Estimation of serum thyroxine concentration was performed in the presence of thyroxine-binding proteins from the same serum and expressed as a fraction (effective thyroxine ratio, ETR * ) of serum thyroxine concentration similarly determined in normal serum. 2. Studies of serum from hyperthyroid and hypothyroid patients and euthyroid patients with and without abnormalities of serum thyroxine-binding proteins indicate a high order of specificity of the ETR in defining abnormal thyroid status irrespective of serum binding protein abnormality. 3. If confirmed in a larger series, ETR should eliminate the need for serum T3 and the free thyroxine index.
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