Abstract
3660 Background: The role of hepatic artery infusion (HAI) has been controversial, and its use often has been empiric without the benefit of pharmacologic and toxicologic data because a suitable animal model that incorporates prolonged HAI has not been available. The goal of this study is to develop an HAI model nearly identical to humans and to employ this model to evaluate hepatic toxicity for site directed chemotherapy. In such a model, various tumor agents other than the traditional FUDR could be evaluated rapidly for dose determination and timing of administration. Methods: The Yucatan minipig possesses a cytochrome P450 enzyme family with remarkable similarities to the human and microscopic and gross anatomy that also resembles the human liver. In this development program, an hepatic artery catheter was placed via the gastroduodenal artery (GDA) in eight pigs. Continuous infusion of saline was maintained for one to four weeks to establish baseline information. Liver biopsies were done at the time of...
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