A new .GAMMA.-dihydropyrone from Streptomyces sp. as a microtubule association inhibitor toward pronuclear fusion in sea urchin eggs.

Abstract

We made the first systematic search for microbial products that might have PF inhibitory activity using a novel bioassay system with sea urchin eggs. A Streptomyces sp. KO23 was discovered, which produced a novel γ-pyrone with pronounced inhibitory activity toward PF. This paper describes the isolation and structure, together with the biological activity