Abstract
A turn-on probe, which exhibited highly selective and sensitive signaling behaviors toward Fe 3+ over other common metal ions, has been synthesized and confirmed by 1 H NMR, 13 C NMR, IR and MS. The addition of Fe 3+ to the solution of probe induced a remarkable UV-Vis and fluorescence enhancement along with obvious color change detected by the naked eye. The reaction mechanism was also investigated and proposed as that the probe complexed Fe 3+ via a 1:1 binding mode, and the subsequent complexation caused the ring-opening of the rhodamine spirolactam and thereby the changes of absorbance and fluorescence. These remarkable properties may allow Fe 3+ to be detected directly in the presence of the other examined competing metal ions. Then, cells experiments showed that the probe could permeate through cell membranes and react to Fe 3+ within living cells. Additionally, the probe was further used for detecting Fe 3+ ions in living mouse which exhibited excellent fluorescence imaging.
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