Abstract
A new flavone C-glycoside, isovitexin 6″-O-E-p-coumarate (1) and two known flavonoid glycosides—quercetin 3-O-β-D-glucuronopyranoside (2) and isoorientin (3)—were isolated from an ethanol extract of aerial parts of Clematis rehderiana. Their structures were determined by spectroscopic methods. The antioxidant effects of the two flavone C-glycosides were evaluated by both the MTT and DPPH assays. Compound 1 showed potent activities against H2O2-induced impairment in PC12 cells within the concentration range tested, whereas compound 3 scavenged DPPH radical strongly, with an IC50 value of 13.5 μM.
Highlights
The genus Clematis (Ranunculaceae), which comprises about 300 species, is widespread throughout the World
In order to provide some knowledge for better usage of the Clematis resources, we have investigated the chemical constituents and antioxidant activity of Clematis rehderiana from Yunnan
We report here the isolation and characterization of one new and two known flavonoid glycosides from this plant, as well as antioxidant assay results for two of these compounds
Summary
The genus Clematis (Ranunculaceae), which comprises about 300 species, is widespread throughout the World. It is reported that 77 Clematis species have been used in traditional Chinese medicine, of which 32 are found in Yunnan province [3]. We report here the isolation and characterization of one new and two known flavonoid glycosides from this plant, as well as antioxidant assay results for two of these compounds.
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