A new fast-dependent time-modified relationship between basal plasma glucose levels and the early glucose response to oral glucose loading in normal human subjects

Abstract

Plasma glucose responses to 50 g oral glucose loads were measured in 17 young healthy males during the morning and the afternoon after 4-h and 12-h fasts. After 4-h fasts certain glucose response values correlated significantly with the basal glucose values ( P < 0.014) in both the morning and the afternoon tests, and are described as “fast-dependent” relationships. No significant correlations were found after 12-h fasts either in the morning or the afternoon. The “fastdependent ” relationships are also “time-modified”, as demonstrated by markedly different morning and afternoon regression equations.