A New Enzyme Test for the Differential Diagnosis of Jaundice.

Abstract

s1 February 1964A New Enzyme Test for the Differential Diagnosis of Jaundice.G. Thomas Passananti, Ph.D., Glenn E. Drewyer, M.D., F.A.C.P.G. Thomas Passananti, Ph.D.Search for more papers by this author, Glenn E. Drewyer, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-326_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe presence of guanase in liver has been known since 1928, yet no attempt has been made to utilize this enzyme in the assessment of liver function or as an indicator of the various types of liver diseases. We reported that the presence of this enzyme in the peripheral circulation as the result of changes in the liver cell has formed the basis of a laboratory diagnostic procedure for the differential diagnosis of jaundice.Guanase is an enzyme that catalyzes a step in the degradation of purines. Assay for its activity is based on guanine disappearance and xanthine production (guanine... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: G. Thomas Passananti, Ph.D.; Glenn E. Drewyer, M.D., F.A.C.P.Affiliations: Flint, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1964Volume 60, Issue 2_Part_1Page: 326-326KeywordsEnzymesLiverLiver diseasesPurinesResearch laboratories ePublished: 1 December 2008 Issue Published: 1 February 1964 PDF downloadLoading ...