Abstract
BackgroundThe point of phase singularity (PS) is considered to represent a spiral wave core or a rotor in cardiac fibrillation. Computational efficiency is important for detection of PS in clinical electrophysiology. We developed a novel algorithm for highly efficient and robust detection of PS.MethodsIn contrast to the conventional method, which calculates PS based on the line integral of the phase around a PS point equal to ±2π (the Iyer-Gray method), the proposed algorithm (the location-centric method) looks for the phase discontinuity point at which PS actually occurs. We tested the efficiency and robustness of these two methods in a two-dimensional mathematical model of atrial fibrillation (AF), with and without remodeling of ionic currents.Results1. There was a significant association, in terms of the Hausdorff distance (3.30 ± 0.0 mm), between the PS points measured using the Iyer-Gray and location-centric methods, with almost identical PS trajectories generated by the two methods. 2. For the condition of electrical remodeling of AF (0.3 × ICaL), the PS points calculated by the two methods were satisfactorily co-localized (with the Hausdorff distance of 1.64 ± 0.09 mm). 3. The proposed location-centric method was substantially more efficient than the Iyer-Gray method, with a 28.6-fold and 28.2-fold shorter run times for the control and remodeling scenarios, respectively.ConclusionWe propose a new location-centric method for calculating PS, which is robust and more efficient compared with the conventionally used method.
Highlights
Ventricular fibrillation (VF) is the most common cause of death for patients with structural heart disease [1, 2], and atrial fibrillation (AF) is associated with 15~25% cause of ischemic stroke [3]
There was a significant association, in terms of the Hausdorff distance (3.30 ± 0.0 mm), between the Phase singularity (PS) points measured using the Iyer-Gray and location-centric methods, with almost identical PS trajectories generated by the two methods
For the condition of electrical remodeling of AF (0.3 × ICaL), the PS points calculated by the two methods were satisfactorily co-localized
Summary
Ventricular fibrillation (VF) is the most common cause of death for patients with structural heart disease [1, 2], and atrial fibrillation (AF) is associated with 15~25% cause of ischemic stroke [3]. Detecting PS points from fibrillatory spiral waves is a complicated procedure, and requires to define a descriptor for time- and space-dependent progression of action potentials, which is defined as a phase [10]. We have developed a new efficient location-centric method for identifying PS points. Our new method for detecting PS depends only on the change in voltage at a local site. This feature shows a clear contrast with the conventional method by Iyer-Gray, which requires voltage information at the neighboring sites. The point of phase singularity (PS) is considered to represent a spiral wave core or a rotor in cardiac fibrillation. We developed a novel algorithm for highly efficient and robust detection of PS
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