Abstract
To develop probes for rapid, selective, and sensitive detection of the virulent cyanide is of great importance in both environmental and biological science. Bearing excellent properties of the fluorescent probes, the fluorescent probes for cyanide with red fluorescent emission are even more appealing. Based on the strong nucleophilic addition reaction of cyanide anion with the polarized CN bond under mild conditions, we herein report a new “Donor-two-acceptor” fluorescent probe, (E)-6-hydroxy-5-(2-(1,3,3-trimethyl-3H-indol-1-ium-2-yl)vinyl)naphthalene-2-sulfonate, sodium salt, for cyanide detection. Through NMR and X-ray diffraction analysis, we characterized the products and further confirmed the detection mechanism. This probe features remarkable large Stokes shift and shows a rapid, highly selective, and sensitive detection process for cyanide with significant turn-off fluorescent responses. The potential application of this new fluorescent probe was demonstrated by fluorescent imaging of cyanide in living cells.
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