A new diet for autosomal dominant polycystic kidney disease (381.1)

Abstract

Background: Recent studies indicate Autosomal Dominant Polycystic Kidney Disease (ADPKD) progression is hastened by excess dietary protein, salt, and dietary acids, and slowed by increased water intake. The aim of this study is to determine the extent to which the Kansas PKD diet can control these factors.Methods: Six adults with ADPKD at the University of Kansas Medical Center Kidney Clinic were enrolled. Participants followed their usual diet for one week and the Kansas PKD diet for the following 4 weeks. Changes in dietary protein, salt and net endogenous acid production (NEAP) were assessed from diet records and changes in osmolality, sodium, urea, and net acid excretion were calculated by averaging 24‐hour urine collections taken at each visit, baseline (day 8) and study end (day 36).Results: The Kansas PKD diet resulted in individuals having decreases in dietary protein (‐27%) and sodium (‐40%), NEAP (‐104%), urine osmolality (‐25%), urinary sodium excretion (‐29%), urea (‐17%), and net acid excretion (‐34%) on day 36.Conclusion: This pilot study demonstrated beneficial changes in the dietary factors known to affect ADPKD progression. Future studies will evaluate structural and functional changes in the kidney while following the Kansas PKD diet and participant acceptability in a larger sample.Key Words: Polycystic Kidney Disease, diet, nutrition, dietary acidsGrant Funding Source: Supported by the University of Kansas Medical Center Kidney Institute and Frontiers Pilot StudyGrant