A new device for chronic multielectrode recordings in awake behaving monkeys

Abstract

Event Abstract Back to Event A new device for chronic multielectrode recordings in awake behaving monkeys Orlando Galashan1, Hanna Rempel1, Andreas K. Kreiter1 and Detlef Wegener1* 1 University of Bremen, Brain Research Institute, Departement of Theoretical Neurobiology, Germany Neurophysiological studies on brain function often require to obtain data from many neurons at the same time, and accordingly, several techniques for chronic implantation of multi-electrode arrays have been developed. However, disadvantages of many of these techniques are that they (a) do not allow for controlled movement of electrodes, or movement in one direction only; (b) do not allow for fast and easy replacement of electrodes; (c) have been designed for electrophysiological measurements in the cortex of small animals (rodents and birds) and are not suitable for the work with non-human primates, and (d) are either difficult to produce or very expensive. We here present a new micro-drive array that overcomes these limitations and permits chronic recordings of single cell activity and local field potentials over prolonged periods of time. The system fulfills the specific requirements for multi-electrode recordings in awake behaving primates. It allows for movement of electrodes in forward and backward directions in small steps and for a distance within the tissue of up to 10mm. The entire set of electrodes can be exchanged in very short time and without the need of any additional surgical procedure or anesthetic intervention and electrodes can be (re-)inserted into the cortex in a precisely defined manner. The micro-drive array permits sterile closure of the trepanation, is of low cost and can easily be produced. We present first data obtained with the new array to approve functionality of the system. Neuronal signals were recorded from primary visual cortex over a period of three months. We demonstrate that the system allows for stable and reproducible recordings of population receptive fields in different depths of the visual cortex and over many recording sessions. Single cell activity was recorded even after many weeks following initial implantation of the array. Conference: Bernstein Conference on Computational Neuroscience, Frankfurt am Main, Germany, 30 Sep - 2 Oct, 2009. Presentation Type: Poster Presentation Topic: Neurotechnology and brain computer interfaces Citation: Galashan O, Rempel H, Kreiter AK and Wegener D (2009). A new device for chronic multielectrode recordings in awake behaving monkeys. Front. Comput. Neurosci. Conference Abstract: Bernstein Conference on Computational Neuroscience. doi: 10.3389/conf.neuro.10.2009.14.110 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Aug 2009; Published Online: 27 Aug 2009. * Correspondence: Detlef Wegener, University of Bremen, Brain Research Institute, Departement of Theoretical Neurobiology, Bremen, Germany, wegener@brain.uni-bremen.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Orlando Galashan Hanna Rempel Andreas K Kreiter Detlef Wegener Google Orlando Galashan Hanna Rempel Andreas K Kreiter Detlef Wegener Google Scholar Orlando Galashan Hanna Rempel Andreas K Kreiter Detlef Wegener PubMed Orlando Galashan Hanna Rempel Andreas K Kreiter Detlef Wegener Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.