A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria

Hao-Fu Dai,Zhen-Chang Wen,Jiao Wu,Dong-Mei Que,Wen-Li Mei,Yu-Juan Gan

doi:10.3390/molecules14093694

Hao-Fu Dai, Zhen-Chang Wen + Show 4 more

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https://doi.org/10.3390/molecules14093694

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Abstract

A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by MTT method.

Highlights

The latex of Antiaris toxicaria (Pers.) Lesch (Moraceae) has been the main source of the poisonous principle in dart and arrow poisons prepared throughout southeastern Asia, from Burma to China and Indonesia [1]
Its toxicity is due to the presence of a complex mixture of cardenolide glycosides [2,3]
Molecules 2009, 14 agents from tropical medicinal plants in Hainan Province, China, three new cytotoxic cardenolides named toxicarioside E, F, and G have been isolated from the latex of A. toxicaria [6,7]

Summary

Introduction

The latex of Antiaris toxicaria (Pers.) Lesch (Moraceae) has been the main source of the poisonous principle in dart and arrow poisons prepared throughout southeastern Asia, from Burma to China and Indonesia [1]. Previous studies of the toxicity of this plant in Indonesia or Malaysia led to the isolation of cardenolides from the latex, seeds, and stems [4,5]. Molecules 2009, 14 agents from tropical medicinal plants in Hainan Province, China, three new cytotoxic cardenolides named toxicarioside E, F, and G have been isolated from the latex of A. toxicaria [6,7]. In continuation of our search for cytotoxic constituents, a new nor-cardenolide, named toxicarioside H (1) was obtained.

Results

Conclusion