Abstract
The title Schiff base compound, C15H13NO2, crystallizes in a new crystal form in the space group P212121, which is different from the monoclinic P21/n space group reported previously [De et al. (2009 ▸). Indian J. Chem. Sect. B, 48, 595-598]. An intra-molecular O-H⋯N hydrogen bond occurs between the hy-droxy and azomethine moieties. In the crystal, mol-ecules are linked by weak C-H⋯O hydrogen bonds into supra-molecular chains propagating along the b-axis direction with a C(8) graph-set motif. The contribution of these two contacts in Hirshfeld surface area are around 19 and 21%, respectively. The title compound was screened for its anti-bacterial activity against two gram-negative (Escherichia coli and Salmonella typhimurium) and one gram-positive (Staphyloccus aureus) bacteria. The results of this study reveal that this Schiff base shows good activity against only one bacterium, i.e. Salmonella typhimurium.
Highlights
The title Schiff base compound, C15H13NO2, crystallizes in a new crystal form in the space group P212121, which is different from the monoclinic P21/n space group reported previously [De et al (2009)
Molecules are linked by weak C— HÁ Á ÁO hydrogen bonds into supramolecular chains propagating along the b-axis direction with a C(8) graph-set motif
The results of this study reveal that this Schiff base shows good activity against only one bacterium, i.e. Salmonella typhimurium
Summary
Schiff bases (Wang et al, 2008) are versatile ligands synthesized from the condensation of primary amines with carbonyl groups. These compounds have been shown to exhibit a broad range of biological activities, including antifungal, antibacterial, anti-malarial, antiproliferative, anti-inflammatory, antiviral and antipyretic properties (Dhar & Taploo, 1982; Przybylski et al, 2009). We report the structural characterization using X-ray diffraction of the title Schiff base derived from salicylaldehyde, including an investigation of the Hirshfeld surfaces and its antimicrobial activity against two gram-negative (Escherichia coli and Salmonella typhimurium) and one grampositive (Staphyloccus aureus) bacteria. It has been proposed that molecules showing thermochromism are planar and those showing photochromism are non-planar (Moustakali-Mavridis et al, 1980; Hadjoudis et al, 1987)
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