Abstract
Herein, a novel coumarin-based fluorescent probe ( FS3 ) was designed, synthesized, and characterized. It exhibited significant fluorescence quenching in the presence of Zn 2+ ions. Just a minor alteration occurred in the fluorescence intensity of FS3 in the presence of other metals studied. The limit of detection for the determination of Zn 2+ by FS3 was calculated to be 3.43 × 10 −9 M. Since the Job’s graph of 1/(F 0 –F) and 1/[Zn 2+ ] had a linear fit, it was determined that the binding stoichiometry between the FS3 and Zn 2+ was 1:1. The association constant of the system was found to be 2.39 × 10 4 M − 1 and confirmed by ESI-MS and FT-IR. It was demonstrated that the developed highly reversible sensor system works by performing real sample analysis. Moreover, the FS3 which has shown no toxicity and displayed a strong fluorescence image will act as an efficient and non-destructive sensor for the determination of Zn 2+ in living organisms. • A novel coumarin-based fluorescent probe (FS3) was designed, synthesized, and characterized. • Significant fluorescence quenching was observed in the presence of Zn 2+ ions. • Stoichiometry between the FS3 and Zn 2+ was 1:1. • The association constant for Zn 2+ binding with FS3 was found to be 2.39 × 10 4 M −1 according to the Benesi-Hildebrand method.
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