Abstract
Research in cancer chemotheraphy has become a problem of selectivity. Liposomes, as a specific drug delivery system, have been largely proposed. In this paper we show proof of the selective action of liposomes, bearing Protein A on their surface, on tumoural cells in culture in the presence of monoclonal antibodies. From a pharmaceutical point of view, the detailed technology for specific liposome production was revisited, where protein adsorption on the surface was investigated by exclusion chromatography, and targeting was demonstrated by bioassay in cell culture. These were the proposed steps in order to find out the pharmacological action before carrying out further investigations in vivo using liposomes as a drug carrier in cancer therapy.
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