A New Concept for More Biocompliant Bone Cements for Vertebroplasty and Kyphoplasty

Abstract

A series of more biocompliant bone cements with mechanical properties that match those of different vertebral trabecular or cancellous bones for vertebroplasty and kyphoplasty applications, have been developed. The elastic modulus and strength of the bone cements are in a range of 5 to 400 MPa, and 5 to 75 MPa, respectively. The bone cement shows excellent thermal and dimensional stability in simulated body fluid of Ringer's solution at both 37 and 70 degrees C. The elastic modulus, strength, ultimate strain are constant over time at both temperatures and did not alter dimensions. The bone cement has a much lower exothermic temperature during polymerization compared with commercially available poly(methyl methacrylate) bone cements, and has high cohesiveness in liquid environments. It is able to be delivered through an 18 gauge needle ranging from 4 to 6 inches in length and reaches final mechanical properties within 30 min post delivery.