Abstract
Dimeric steroid esters containing an estradiol molecule coupled with a molecule of ethynodiol, cortexo lone, or ethinylandrostenediol respectively, were synthesized. The same method was also used for dimerization of ethynodiol, nortestosterone, and testosterone, and for the preparation of a trimeric androgen consisting of two molecules testosterone linked by one molecule 5-androstene-3β, 17β-diol. The method is based upon the direct esteriflcation of steroid alcohols with steroid hemisuccinates in the presence of N,N'-carbonyldiimidazole. The results of preliminary experiments concerning the biological activity of some of these compounds showed a considerable prolongation of hormonal effect as compared to the respective monomer.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
