Abstract
N-Sulfanilylnorfloxacin was chosen as lead compound to develop a new series of benzenesulfonamidefluoroquinolones (BSFQs). Eight new compounds with different p-substituents on the phenyl group were prepared and their in vitro antibacterial activities were evaluated. The presence of the benzenesulfonylamido groups (BS) bound to the piperazinyl ring shifted the activity of classic antimicrobial fluoroquinolones from being more active against Gram negative to Gram positive strains. Analogs with p-NHCH 3, p-H or p-NO 2 were more active than norfloxacin. QSAR studies through Hansch analysis showed a linear correlation of the activity with electronic distribution (empirical descriptors) along with Sterimol parameters. Small electron–donor groups with hydrophilic properties increase the in vitro activity against Gram positive bacteria.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
