Abstract
A sample of the marine brown alga D. divaricata collected off the coast of Yantai (P.R. China) was dried, powdered, and extracted with the mixture of CHCl3 and MeOH (1:1, v/v). By a combination of silica gel and Sephadex LH-20 column chromatography and preparative TLC, a new cadinane sesquiterpene 1,4-epoxymuurolan-5β-ol (1) was isolated from this species. Its structure was established by detailed MS and NMR spectroscopic analysis, as well as comparison with literature data.
Highlights
Marine brown algae of the genus Dictyopteris are prolific sources of sesquiterpenes, and cadinane is a main carbon skeleton type [1,2,3,4,5,6,7,8]
In our investigations on the structurally interesting and biologically active terpenes from Chinese marine algae, we examined the chemical constituents of D
Molecules 2009, 14 divaricata collected off the coast of Yantai and as a result, a new cadinane sesquiterpene, 1,4epoxymuurolan-5β-ol (1) has been isolated and characterized for the first time
Summary
Marine brown algae of the genus Dictyopteris are prolific sources of sesquiterpenes, and cadinane is a main carbon skeleton type [1,2,3,4,5,6,7,8]. Molecules 2009, 14 divaricata collected off the coast of Yantai and as a result, a new cadinane sesquiterpene, 1,4epoxymuurolan-5β-ol (1) has been isolated and characterized for the first time. This paper reports the isolation and structural elucidation of compound 1 (Figure 1). The concentrated extracts were partitioned between H2O and EtOAc. The EtOAc-soluble fraction was further purified by a combination of silica gel and Sephadex LH-20 column chromatography, as well as preparative TLC, to yield compound 1.
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