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Abstract
Tandem BRCT domains are phophoprotein binding modules. In this issue of Structure, Sun etal. (2017) show that a single BRCT domain in TopBP1 binds tightly and specifically to phosphorylated Bloom syndrome helicase (BLM). This work reveals a novel BRCT binding mode and suggests a similar mechanism for TopBP1 interaction with 53BP1.
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