A new biphasic osteoinductive calcium composite material with a negative Zeta potential for bone augmentation

Ralf Smeets,Dieter Riediger,Jamal M. Stein,Oliver Maciejewski,Andreas Kolk,Marcus Gerressen,Benita Hermanns-Sachweh,Oliver Driemel

doi:10.1186/1746-160x-5-13

Abstract

The aim of the present study was to analyze the osteogenic potential of a biphasic calcium composite material (BCC) with a negative surface charge for maxillary sinus floor augmentation. In a 61 year old patient, the BCC material was used in a bilateral sinus floor augmentation procedure. Six months postoperative, a bone sample was taken from the augmented regions before two titanium implants were inserted at each side. We analyzed bone neoformation by histology, bone density by computed tomography, and measured the activity of voltage-activated calcium currents of osteoblasts and surface charge effects. Control orthopantomograms were carried out five months after implant insertion. The BCC was biocompatible and replaced by new mineralized bone after being resorbed completely. The material demonstrated a negative surface charge (negative Zeta potential) which was found to be favorable for bone regeneration and osseointegration of dental implants.

Highlights

To place an implant in the posterior upper jaw often requires augmentation procedures in order to increase the vertical dimension and obtain sufficient anchorage of the implant in the alveolar bone that bears the implant
A second surgical site is needed in order to harvest the bone; the size of the graft is often limited, and donor site morbidity frequently represents a problem. Bone replacement biomaterials such as demineralized freeze-dried bone allografts and xenografts have been recently used for sinus augmentation with good clinical results and various authors recently reported on the resorption and remodeling of the materials [5,6]
The purpose of our study is to analyze and demonstrate the osteogenic, histologic and radiographic qualities of the biphasic calcium composite material (BCC) bone graft fabricated through the Zeta potential process, which enables production of a bioactive bone graft material with a controlled negative surface charge and which, when placed in apposition to healthy bleeding bone, accelerates the bone growth cascade [15,16]

Summary

Methodology

A new biphasic osteoinductive calcium composite material with a negative Zeta potential for bone augmentation. Ralf Smeets*1,2, Andreas Kolk, Marcus Gerressen, Oliver Driemel, Oliver Maciejewski, Benita Hermanns-Sachweh, Dieter Riediger and. Address: 1Department of Oral and Maxillofacial Surgery, University Hospital Aachen, Aachen, Germany, 2Interdisciplinary Center for Clinical Research (IZKF) 'BIOMAT', RWTH Aachen University, Aachen, Germany, 3Department of Oral and Cranio-Maxillofacial Surgery, Technische Universität, Klinikum rechts der Isar, Munich, Germany, 4Department of Oral and Maxillofacial Surgery, University of Regensburg, Regensburg, Germany, 5Department of Pathology, University Hospital Aachen, Aachen, Germany and 6Department of Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital Aachen, Aachen, Germany. Published: 13 June 2009 Head & Face Medicine 2009, 5:13 doi:10.1186/1746-160X-5-13

Background

Methods

Results and discussion

Tatum H Jr