Abstract
s / Pancreatology 12 (2012) 502–597 513 Results: Subcutaneously administrated cerulein in dosage of 5 and 10 mg/kg resulted in AP in rats, with significant changes in red blood cell deformability and alterations in erythrocyte aggregation. The presence of AP could be confirmed by amylase testing and histological examination. The earliest impairment of the red blood cell deformability could be observed 1 hour after cerulein administration in 10 mg/kg dosage. Conclusion: We found micro-rheological changes in cerulein-induced acute pancreatitis, showing further differences depending on the cerulein dosage and gender. Female animals had the worst rheological results, and the mortality was the highest among them. This model seems to be suitable for further comparative studies.
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