Abstract
A new aromatic annulation reaction based on sequential Horner–Emmons and Claisen condensation reactions is described. The method is high yielding and provides a rapid entry to arylnaphthalenes. The lignan natural products justicidin B 1 , retrojusticidin B 2 , taiwanin C 3 , justicidin E 4 , chinensin 5 and retrochinensin 6 have all been synthesised in good overall yield using this protocol, demonstrating its potential in multiple parallel synthesis. The selective oxidation of diols 34– 36 to the corresponding retrolactones with barium manganate(VI) is also noteworthy.
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