Abstract
A method for the synthesis of diastereomerically pure diamino alcohols and triamines was developed. The products obtained are new asymmetric structural analogs of the anti-TB drug ethambutol. The method involves reductive cleavage of the N-N bond in appropriate functionalized pyrazolidines and 2-pyrazolines under the action of a diborane complex with THF. The cleavage occurs with retention of the configurations of the asymmetric centers of the starting compounds.
Published Version
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