A new approach to the synthesis of 3-amino- and 3-benzoylamino-5-aminoalkyl-1,2,4-triazoles

Abstract

Nickel(II) acetylacetonate for the first time was shown to efficiently catalyze the addition of Boc-protected amino acid hydrazides to the nitrile group of benzoylcyanamide with the formation of the corresponding 3-benzoylamino-substituted 1,2,4-triazoles with the Boc-aminoalkyl group at position 5. A further modification of the latter led, depending on the conditions, to mono- or dihydrochlorides of 1,2,4-triazole-derived amines.