A new approach for the synthesis of N-β-enaminocarbonyl 2-oxazolidinones through ring transformation reactions of uracil

Abstract

The reaction of N1-sulfonyluracil derivatives bearing a 2-hydroxyethyl moiety at the 3-position with NaH under anhydrous conditions at room temperature affords the corresponding 2-oxazolidinone bearing the β-enaminocarbonyl moiety. These products are useful diversifiable precursors toward various β-amino acids and N-heterocyclic compounds.