Abstract
AbstractChromatographic workup for EtOAc (ethyl acetate) extract of an OSMAC (One Strain MAny Compounds)‐modified solid rice culture of the freshwater‐sediment‐derived fungus, Penicillium sp. (S1a1), afforded one new decalin polyketide derivative, tanzawaic acid Z1 (1). The chemical structure of the new derivative was unambiguously established based on extensive 1D (one‐) and 2D (two‐dimensional) NMR (Nuclear Magnetic Resonance) spectroscopic data along with ESI‐HRMS (ElectroSpray Ionization‐High Resolution Mass Spectrometry). Moreover, the relative configuration was determined based on NMR spectroscopic data including a ROESY (Rotational Overhauser Effect SpectroscopY) spectrum. The absolute configuration was suggested on the basis of the specific optical rotation, and biogenetic considerations in comparison with related previously isolated known metabolites from the same fungal strain. In addition, the antioxidant, antibacterial and cytotoxic activities of the new derivative were evaluated. Compound 1 proved to exert a promising antioxidant activity.
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