Abstract
A new antigen-antibody system was recently described in hepatitis B surface antigen (HB<sub>s</sub>Ag)-positive sera. Despite indications of heterogeneity in specificity, the designations "<i>e</i>antigen" and "<i>e</i>antibodies" are used for the system as such in this article. Eight of 17 long-term carriers of HB<sub>s</sub>Ag with a histological picture of chronic persistent hepatitis or chronic aggressive hepatitis carried the<i>e</i>antigen, while none had demonstrable<i>e</i>antibodies in serum. Ten of 12 healthy carriers with e antibodies were blood donors who had donated 95 units of blood; none of these carriers was associated with a reported case of posttransfusion hepatitis. In five individuals in the incubation stage of hepatitis B,<i>e</i>antigen appeared simultaneously with HB<sub>s</sub>Ag but before the rise in transaminase levels. This finding further links<i>e</i>antigen to hepatitis B. (<i>JAMA</i>231:356-359, 1975)
Published Version
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