Abstract
Phytochemical investigation of the roots of Walsura trichostemon, a Thai medicinal plant, provided a new tirucallane, 3-epimesendanin S 12-acetate (1), together with four known compounds, 3-epimesendanin S (2), meliasenin G (3), β-sitosterol (4) and β-sitosterol glucoside (5). Their structures were characterized by intensive spectroscopy including 1 D and 2 D NMR, UV, IR and MS spectrometric analysis. The isolated compounds were evaluated for antibacterial and acetylcholinesterase inhibitory activities. Compounds 1–2 showed antibacterial activity against Bacillus cereus and Bacillus subtilis with MIC values ranging from 16–128 μg/mL. In addition, compound 3 was active against Pseudomonas aeruginosa and Escherichia coli with MIC values of 64 and 128 μg/mL, respectively.
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