Abstract
Alpelisib, an anti-cancer drug with great potential, targets the phosphoinositide 3-kinase (PI3K) pathway, which is commonly dysregulated in various cancer types. Accurate and sensitive quantification of Alpelisib is crucial for optimizing treatment strategies and monitoring therapeutic outcomes. In this study, we have developed the first electrochemical sensor utilizing a modified electrode to precisely determine Alpelisib concentrations. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and Electrochemical impedance spectroscopy (EIS) techniques were extensively employed to investigate the electrochemical behavior of Alpelisib. The modified electrode was constructed by immobilizing multi-walled carbon nanotubes (MWCNTs), iron oxide (Fe3O4), and copper aluminum spinel (CuAl2O4) onto a glassy carbon electrode (GCE). This modification scheme aimed to improve the electrocatalytic activity and selectivity of the electrode towards Alpelisib. Subsequently, the developed electrode was successfully applied for the detection of Alpelisib in pharmaceutical formulations and biological fluids, thus demonstrating its applicability in real-world scenarios. The limit of detection (LOD) was determined to be 0.036 μM, affirming the sensor’s high sensitivity in detecting low concentrations of Alpelisib.
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