Abstract

• Colorectal cancer (CRC) is a major public health concern • Adenomatous polyps are precursors of CRC and their identification is the basis for population-based CRC screening programs • Current world-wide population-based screening uses guaiac-based fecal occult blood tests (FOBT) which has a sensitivity of 5-30% for adenomatous polyps • Newer fecal immunochemical tests (FITs) use antibodies directed against human globin and have a sensitivity of 20-67% for colonic adenomas • Urine metabolomics has the potential to be a more accurate and patient-friendly screening test for colorectal cancer and precancerous lesions.

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