Abstract
A two step synthesis of 3-alkylthiophenes with an overall yield of 80% is described. The first step, a Grignard reaction, has been considerably improved by decreasing the amount of by-products. The second and key step of the synthesis, the reduction of a benzylic alcohol, has been studied in detail. The best results were obtained with PdCl 2 in acetic acid, at 65°C under atmospheric pressure of H 2.
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